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Anti-Beclin 1 Rabbit pAb (100 μl)
| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Beclin1 rabbit polyclonal antibody |
Gene Name: | Beclin-1 |
Synonyms: | BECN1, ATG6, NVPS30, beclin1, beclin-1, GT197 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Beclin1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Uniprot ID: | Q14457 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse | 1: 500-1: 4000 | kidney |
Background
Plays a central role in autophagy . Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 . Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms.
Images
| Immunofluorescence of paraffin embedded mouse kidney using Beclin1 (GB11228) at dilution of 1:2200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
