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| Reactivity: | Mouse |
| Applications: | FCM |
| Host Species: | Armenian Hamster |
| Isotype: | Armenian Hamster IgG |
| Clonality: | Monoclonal |
| Conjugation: | Biotin |
| Synonyms: | Tumor necrosis factor receptor superfamily member 1B,Tnfrsf1b,Tumor necrosis factor receptor 2,TNF-R2,TNF-RII,TNFR-II,p75,p80 TNF-alpha receptor,CD120b |
| Background: | CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-α and LT-α (also known as TNF-β). In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state. |
| Gene ID: | 21938 |
| SwissProt: | P25119 |
| Concentration: | 0.5 mg/mL |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Storage: | Store at 2~8°C. Do not freeze. |
| Documents: | Please contact us to request the manual |
