Your shopping cart is empty!
Anti-Bone Sialoprotein Rabbit pAb (100 μl)
| Reactivity: | M,R & M,R |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Bone Sialoprotein rabbit polyclonal |
Gene Name: | Bone sialoprotein 2 |
Synonyms: | IBSP, BNSP, BSP, BSP-II, SP-II, Integrin binding sialoprotein, Bone Sialoprotein |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Bone Sialoprotein |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 500-1: 1500 | bone |
IF | Mouse, Rat | 1: 500-1: 1000 | bone |
Background
Bone sialoprotein (BSP) is a component of mineralized tissues such as bone, dentin, cementum and calcified cartilage. BSP is a significant component of the bone extracellular matrix and has been suggested to constitute approximately 8% of all non-collagenous proteins found in bone and cementum. It is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor.
Images
 |
Immunohistochemistry analysis of paraffin-embedded mouse bone using Bone Sialoprotein (GB11588) at dilution of 1: 750 |
Storage
| Storage |
Store at -20°C for one year. Avoid repeated freeze/thaw cycles |
| Storage Buffer |
PBS with 0.02%sodium azide, 100 μg/ml BSA and 50% glycerol. |
