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| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Cystathionine beta-synthase |
Synonyms: | Beta-thionase, Serine sulfhydrase, Cbs, HIP4, Methylcysteine synthase, EC 4.2.1.22, Cbs cystathionine beta-synthase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CBS |
Uniprot ID: | Q91WT9 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus |
Predicted MW. / Observed MW. | 62 kDa / 62 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 1000-1: 2000 | kidney, liver |
IHC/IF | Mouse, Rat | 1: 250-1: 800 | brain |
Background
The CBS gene encodes cystathionine beta-synthase, which catalyzes the first irreversible step of transsulfuration. The CBS enzyme is a homotetramer of 63-kD subunits and requires pyridoxal phosphate and heme for activity. CBS protein is localized in most areas of the brain, but predominantly in the cell bodies and neuronal processes of Purkinje cells and Ammon's horn neurons.
Images
| Western blot analysis of CBS (GB111794) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded rat brain using CBS (GB111794) at dilution of 1: 750 |
| Immunohistochemistry analysis of paraffin embedded mouse brain using CBS (GB111794) at dilution of 1: 750 |
| Immunofluorescent analysis of paraffin embedded mouse brain using CBS (GB111794) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
