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Anti-CD105 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | IHC & IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CD105 rabbit polyclonal |
Gene Name: | Endoglin |
Synonyms: | Cell surface MJ7/18 antigen, CD105, Eng, Edg, FLJ41744, HHT1, ORW, ORW1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CD105 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 500-1: 1000 | colon carcinoma, liver cancer, |
IF | Human | 1: 500-1: 1000 | liver cancer, ovarian cancer |
Background
Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis.
Images
| Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using CD105 (GB113377) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human liver cancer using CD105 (GB113377) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin-embedded human ovarian cancer using CD105 (GB113377) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed humanliver cancer using CD105 (GB113377) at dilution of 1: 1000 |
| Immunofluorescent analysis of paraformaldehyde-fixed human ovarian cancer using CD105 (GB113377) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
