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| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Low affinity immunoglobulin gamma Fc region receptor II |
Synonyms: | Fc gamma receptor IIB, Fc-gamma RII, Fc-gamma-RIIB, FcRII, IgG Fc receptor II beta, Lymphocyte antigen 17, Ly-17, CD32, Fcgr2, Fcgr2b |
Immunogen: | Recombinant protein corresponding to Human CD32 |
Uniprot ID: | P31994 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 34 kDa / 40-50 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | Raji |
IHC/IF | Human | 1: 400-1: 800 | diffuse large b-cell lymphoma, tonsil, liver, placenta |
Background
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of antigen-antibody complexes from the circulation and modulation of antibody production by B-cells. Isoform IIB1 and isoform IIB1' form caps but fail to mediate endocytosis or phagocytosis. Isoform IIB2 can mediate the endocytosis of soluble immune complexes via clathrin-coated pits. Isoform IIB1 and isoform IIB2 can down-regulate B-cell, T-cell, and mast cell activation when coaggregated to B-cell receptors for AG (BCR), T-cell receptors for AG (TCR), and Fc receptors, respectively.
Images
| Western blot analysis of CD32 (GB114833) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human diffuse large b-cell lymphoma using CD32 (GB114833) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human liver using CD32 (GB114833) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human tonsil using CD32 (GB114833) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human placenta using CD32 (GB114833) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
