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| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 |
Synonyms: | ADP ribosyl cyclase 1, cADPr hydrolase 1, CD38, CD38 molecule, Cyclic ADP ribose hydrolase 1, T10 |
Immunogen: | Recombinant protein corresponding to Human CD38 |
Uniprot ID: | P28907 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 34 kDa / 45 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | Molt4, Jurkat, THP-1 |
IHC/IF | Human | 1: 1000-1: 2000 | tonsil, olfactory neuroblastoma |
Background
CD38 molecule(CD38) Homo sapiens The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants.
Images
| Western blot analysis of CD38 (GB114831) at dilution of 1: 800 |
| Immunohistochemistry analysis of paraffin embedded human tonsil using CD38 (GB114831) at dilution of 1: 1500 |
| Immunohistochemistry analysis of paraffin embedded human olfactory neuroblastoma using CD38 (GB114831) at dilution of 1: 1500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
