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| Reactivity: | M,R & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CD44 rabbit polyclonal antibody |
Gene Name: | CD44 antigen |
Synonyms: | Extracellular matrix receptor III, ECMR-III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Hermes antigen, Hyaluronate receptor, Ly-24, CD44, PGP-I |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CD44 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. | 86 kDa |
Observed MW. | 95 kDa |
Uniprot ID: | P15379, P26051 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 100-1: 300 | PC-12, RAW 264.7 |
IHC/IF | Mouse, Rat | 1: 150-1: 600 | colon, liver, spleen, stomach |
Background
CD44 is the receptor for hyaluronic acid (HA). It mediates cell to cell and cell matrix interactions through its affinity for HA. Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. High protein heterogeneity due to several alternative splicing and post translational modification events. CD44R represents a heterogeneous group of CD44 variant isoforms expressed constitutively in epithelial cells and monocyte lineage cells and can be upregulated in activated leukocytes.
Images
| Western blot analysis of CD44 (GB112054) at dilution of 1: 100 |
| Immunohistochemistry of paraffin embedded rat colon using CD44 (GB112054) at dilution of 1: 150 (400x lens) |
| Immunohistochemistry of paraffin embedded rat stomach using CD44 (GB112054) at dilution of 1: 150 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse liver using CD44 (GB112054) at dilution of 1: 150 (400x lens) |
| Immunohistochemistry of paraffin embedded mouse spleen using CD44 (GB112054) at dilution of 1: 150 (400x lens) |
| Immunohistochemistry of paraffin embedded rat spleen using CD44 (GB112054) at dilution of 1: 150 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
