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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CD99 rabbit polyclonal antibody |
Gene Name: | CD99 antigen |
Synonyms: | 12E7, MIC2, MIC2X, MIC2Y, E2 antigen, CD99, Protein MIC2, T-cell surface glycoprotein E2, HBA71, CD99-H |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CD99 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 19 kDa |
Observed MW. | 32 kDa |
Uniprot ID: | P14209 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human | 1: 500-1: 1000 | Jurkat, THP-1, HUVEC |
Background
CD99, also known as MIC2, is a heavily O-glycosylated transmembrane protein involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. CD99 is broadly distributed on many cell types, with particularly strong expression on human cortical thymocytes, Ewing’s sarcoma cells and peripheral primitive neuroectodermal tumors . In normal cells, CD99 has been functionally implicated in cell adhesion, migration, apoptosis, differentiation, activation, and proliferation of lymphocytes and monocyte extravasation and transport of several transmembrane proteins .CD99 is expressed in many types of tumors and has been used for differential diagnosis of conventional Ewing sarcoma. It has been actively pursued as a therapeutic target. On the other hand, CD99 may also play a tumor suppressor role in other tumors, such as Hodgkin’s lymphomas, osteosarcomas, and pancreatic tumors.
Images
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Western blot analysis of CD99-H (GB11970) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
