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Anti-CHMP1B Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Charged multivesicular body protein 1b |
Synonyms: | C10orf2, C18 ORF2, C18orf2, CHMP1.5, CHMP1B, chromatin modifying protein 1B, hVps46 2, Vps46 2 |
Immunogen: | Recombinant protein corresponding to Human CHMP1B |
Uniprot ID: | Q7LBR1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 22 kDa / 26 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 800-1: 2000 | skeletal muscel |
Background
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released.
Images
| WB analysis of CHMP1B(GB115666). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
