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Anti-CLIP170 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CLIP170 rabbit polyclonal antibody |
Gene Name: | CAP-Gly domain-containing linker protein 1 |
Synonyms: | Cytoplasmic linker protein 170, CLIP-170, Restin, Clip1, Kiaa4046, Rsn |
Immunogen: | Recombinant protein corresponding to Mouse CLIP170 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 162 kDa |
Observed MW. | 180 kDa |
Uniprot ID: | P30622, Q922J3, Q9JK25 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain |
Background
CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1.
Images
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Western blot analysis of clip (GB111068) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
