Your shopping cart is empty!
Anti-CSNK2A2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | CKII alpha prime polypeptide rabbit polyclonal antibody |
Gene Name: | Casein kinase II subunit alpha |
Synonyms: | Csnk2a2, CSNK2A2, CK2A2, CSNK2A1, CK2alpha, Casein kinase 2 alpha 2 |
Immunogen: | Recombinant protein corresponding to Mouse CSNK2A2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 41 kDa |
Observed MW. | 41 kDa |
Uniprot ID: | P19784, O54833 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, testis, lung |
Background
Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1.
Images
|
|
Western blot analysis of CK2a (GB11737) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
