Reactivity: | M,R & M,R |
Applications: | IHC & IF |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Full Name: | CYP2D6 rabbit polyclonal |
Gene Name: | Cytochrome P450 2D6 |
Synonyms: | CYPIID6, Cholesterol 25-hydroxylase, Cytochrome P450-DB1, Debrisoquine 4-hydroxylase, CYP2DL1, CYP2D6 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human CYP2D6 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Mouse, Rat | 1: 1500-1: 3000 | pituitary gland |
IF | Mouse, Rat | 1: 1000-1: 2000 | pituitary gland |
Background
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant.
Images
Immunohistochemistry analysis of paraffin-embedded mouse pituitary gland using CYP2D6 (GB112045) at dilution of 1: 3000 | |
Immunohistochemistry analysis of paraffin-embedded rat pituitary gland using CYP2D6 (GB112045) at dilution of 1: 3000 | |
Immunofluorescent analysis of paraformaldehyde-fixed mouse pituitary gland using CYP2D6 (GB112045) at dilution of 1: 2000 | |
Immunofluorescent analysis of paraformaldehyde-fixed rat pituitary gland using CYP2D6 (GB112045) at dilution of 1: 2000 |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |