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Anti-Cytochrome P450 3A4/CYP3A4 Rabbit pAb (100 μl)
| Reactivity: | H & H |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Cytochrome P450 3A4 |
Synonyms: | Albendazole sulfoxidase, Cholesterol 25-hydroxylase, Nifedipine oxidase, Quinine 3-monooxygenase, CYP3A4, CYP3A3, Cytochrome P450 HLp |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Cytochrome P450 3A4 |
Uniprot ID: | P08684 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum, Cell membrane |
Predicted MW. / Observed MW. | 57 kDa / 57 kDa |
Product Usage Information
WB | Human | 1: 500-1: 1000 | HepG2, HeLa, Jurkat |
IHC/IF | Human | 1: 300-1: 1000 | liver |
Background
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Images
| Western blot analysis of CytochromeP4503 A4 (GB112021) at dilution of 1: 1000 |
| Immunohistochemistry analysis of paraffin embedded human liver using CytochromeP4503A4 (GB112021) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
