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| Reactivity: | H,M,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Extracellular calcium-sensing receptor |
Synonyms: | Calcium Sensing Receptor, CAR, CASR, FHH, FIH, GPRC2A, HHC, HHC1, NSHPT, PCAR1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CASR |
Uniprot ID: | Q9QY96 |
Isotype: | lgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Product Usage Information
IHC/IF | Human, Mouse, Rat | 1: 50-1: 150 | kidney |
Background
G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis. Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone in parathyroid glands. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation.
Images
| Immunohistochemistry analysis of paraffin embedded human kidney using CaSR (GB115579) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using CaSR (GB115579) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded mouse kidney using CaSR (GB115579) at dilution of 1: 150 |
| Immunohistochemistry analysis of paraffin embedded rat kidney using CaSR (GB115579) at dilution of 1: 150 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
