Your shopping cart is empty!
Anti-Caldesmon/CDM Rabbit pAb (100 μl)
| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Non-muscle caldesmon |
Synonyms: | CDM, L-caldesmon, Cald1, CAD, CALD1, Caldesmon 1, H CAD, LCAD, NAG22, Caldesmon 1 Isoform 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human Caldesmon |
Uniprot ID: | |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Images
IHC/IF | Rat | 1: 1000-1: 4000 | uterus, stomach |
Background
This gene encodes a calmodulin and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids.Binding of caldesmon to actin is weakened by phosphorylation and by calmodulin in the presence of calcium. Caldesmon-1 is encoded by a single gene, which is spliced to generate a widely distributed low molecular weight form and a smooth muscle specific high molecular weight form. Caldesmon-1 is phosphorylated by the cyclin dependent kinase cdc2 and Erk1/2 MAP kinase, both of which prevent the activity of caldesmon-1. Phosphorylation of caldesmon by cdc2 is required for passage of cells through mitosis.Phosphorylation by Erk1/2 is important in regulating smooth muscle contraction .
Images
| Immunohistochemistry analysis of paraffin embedded rat uterus using caldesmon (GB11959) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin embedded rat stomach using caldesmon (GB11959) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
