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Anti-Cathepsin D Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Cathepsin D rabbit polyclonal antibody |
Gene Name: | Cathepsin D |
Synonyms: | Ctsd, CatD, CD, CLN10, CPSD, Epididymis secretory sperm binding protein Li 130P, HEL S 130P, Lysosomal aspartyl peptidase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Cathepsin D |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Lysosome, Secreted |
Uniprot ID: | P07339, P18242 |
Product Usage Information
IHC/IF | Human, Mouse | 1: 200-1: 400 | liver |
Background
CTSD(Cathepsin D) is also named as CPSD,belongs to the peptidase A1 family.It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. The prepro-CTSD isoform has a molecular mass of 52 kDa, the pro-CTSD 48 kDa and the mature CTSD 32 kDa. It is a lysosomal acid protease found in neutrophils and monocytes and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.Defects in CTSD are the cause of neuronal ceroid lipofuscinosis type 10 (CLN10).This antibody is specific to CTSD.
Images
| Immunofluorescence analysis of paraffin embedded mouse liver using cathepsinD (GB111861) at dilution of 1:200 (260x lens) |
| Immunofluorescent analysis of paraformaldehyde-fixed human breast cancer using Cathepsin D (GB111861) at dilution of 1: 400 |
| Immunofluorescent analysis of paraformaldehyde-fixed mouse iver using Cathepsin D (GB111861) at dilution of 1: 400 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
