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| Reactivity: | R |
| Applications: | IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Cdk9 rabbit polyclonal |
Gene Name: | Cyclin-dependent kinase 9 |
Synonyms: | Cell division protein kinase 9, Cdk9, C2k, CDC2L4, CTK1, PITALRE, TAK |
Immunogen: | Recombinant protein corresponding to Mouse Cdk9 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IF | Rat | 1: 500-1: 1000 | brain |
Background
CDK9 (cyclin-dependent kinase 9) is a member of the cyclin-dependent protein kinase family. It is involved in the regulation of transcription. CDK9 is a member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex. It regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardic myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.
Images
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Immunohistochemistry analysis of paraffin-embedded rat brain using Cdk9 (GB111389) at dilution of 1: 600 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
