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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Chk1 rabbit polyclonal antibody |
Gene Name: | Serine/ threonine-protein kinase Chk1 |
Synonyms: | CHEK1, Chk1, checkpoint kinase 1 |
Immunogen: | Recombinant protein corresponding to Mouse Chk1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 45 kDa |
Observed MW. | 45 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | spleen, lung |
Background
Checkpoint kinase 1, commonly referred to as Chk1, is a serine/threonine-specific protein kinase that are involved in cell cycle control. Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival. Chk1 is required for the initiation of DNA damage checkpoints and has recently been shown to play a role in the normal (unperturbed) cell cycle. Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. In addition to mediating cell cycle checkpoints, Chk1 also contributes to DNA repair processes, gene transcription, embryo development, cellular responses to HIV infection and somatic cell viability.
Images
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Western blot analysis of CHK1 (GB11633) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |