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Anti-D4 GDI Rabbit pAb (100 μl)
| Reactivity: | H,M & M |
| Applications: | WB & IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | D4 GDI rabbit polyclonal |
Gene Name: | Rho GDP-dissociation inhibitor 2 |
Synonyms: | ARHGDIB, D4, GDIA2, GDID4, Ly-GDI, LYGDI, RAP1GN1, Rho GDI 2, Rho-GDI beta, RhoGDI2, D4 GDP dissociation inhibitor |
Immunogen: | Recombinant protein corresponding to Mouse D4 GDI |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | |
Predicted MW. | 23 kDa |
Observed MW. | 23 kDa |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse | 1: 1000-1: 2000 | spleen, lung |
IHC | Mouse | 1: 3000-1: 6000 | bone, lung, placenta, spleen |
Background
ARHGDIB, also known as RhoGDI2, is a conserved member of the RhoGDI family and plays an important role in cell migrations. It regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. It is mainly in hematopoietic, endothelial, and epithelial cells. It has been linked to tumorigenesis and metastasis. RhoGDI2 expression is downregulated in several cancer types, such as bladder, lung and lymphoma, but is upregulated in prostate and gastric cancer.
Images
| Western blot analysis of D4 GDI (GB113556) at dilution of 1: 2000 |
| Immunohistochemistry analysis of paraffin-embedded mouse bone using D4 GDI (GB113556) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded mouse lung using D4 GDI (GB113556) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded mouse placenta using D4 GDI (GB113556) at dilution of 1: 6000 |
| Immunohistochemistry analysis of paraffin-embedded mouse spleen using D4 GDI (GB113556) at dilution of 1: 6000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |