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Anti-DACH1 Rabbit pAb (100 μl)
| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Dachshund homolog 1 |
Synonyms: | DACH, DACH1, Dachshund homolog 1, Dachshund-1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse DACH1 |
Uniprot ID: | Q9QYB2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 78 kDa / 103 kDa |
Product Usage Information
WB | Human, Mouse | 1: 300-1: 800 | kidney |
Background
Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1 . Binds to chromatin DNA via its DACHbox-N domain.
Images
| Western blot analysis of DACH1 (GB114605) at dilution of 1: 800 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
