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| Reactivity: | R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DAG1 rabbit polyclonal antibody |
Gene Name: | Dystroglycan |
Synonyms: | Dag1, DAG1, 156DAG, A3a, AGRNR, DAG, MDDGC7, MDDGC9, MDDGA9, dystroglycan 1, LGMDR16 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse DAG1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted, Membrane, Cytoplasm, Nucleus |
Uniprot ID: | Q62165 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Rat | 1: 500-1: 2000 | brain, cerebral infarction, prefrontal lobe |
Background
In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin [alpha]-2 laminin in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables.
Images
 | Immunohistochemistry of paraffin embedded rat brain using DAG1 (GB11714) at dilution of 1:700 (400x lens) |
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Immunohistochemistry of paraffin embedded rat cerebral infarction using DAG1 (GB11714) at dilution of 1:700 (400x lens) |
| Immunofluorescence of paraffin embedded rat prefrontal lobe using DAG1 (GB11714) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
