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Anti-DBC-1 Rabbit pAb (100 μl)
| Reactivity: | H,M & M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DBC-1 rabbit polyclonal antibody |
Gene Name: | Cell cycle and apoptosis regulator protein 2 |
Synonyms: | Cell division cycle and apoptosis regulator protein 2, Ccar2, DBIRD complex subunit KIAA1967, KIAA1967, NET35, p30 DBC, DBC-1 |
Immunogen: | Recombinant protein corresponding to Mouse DBC-1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Cytoplasm |
Predicted MW. | 103 kDa |
Observed MW. | 130 kDa |
Uniprot ID: | Q8N163, Q8VDP4 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | fetal rat |
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | brain, heart |
Background
DBC1, also named as DBCCR1 and FAM5A, inhibits cell proliferation by negative regulation of the G1/S transition. It mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.DBC1 is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.
Images
| Western blot analysis of DBC1 (GB111647) at dilution of 1: 500 |
| Immunohistochemistry of paraffin embedded rat brain using DBC1 (GB111647) at dilution of 1: 600 (400x lens) |
 | Immunohistochemistry of paraffin embedded rat heart using DBC1 (GB111647) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
