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| Reactivity: | R |
| Applications: | IHC |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DLL1 rabbit polyclonal antibody |
Gene Name: | Delta-like protein 1 |
Synonyms: | DLL1, DELTA1, DL1, Delta, Delta-like 1, delta like canonical Notch ligand 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse DLL1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Apical cell membrane |
Uniprot ID: | Q61483, P97677 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 200-1: 800 | brain, lung, spinal cord |
Background
Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch. Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4. Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex.
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Immunohistochemistry of paraffin embedded mouse brain using DLL1 (GB11320) at dilution of 1:400 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse spinal cord using DLL1 (GB11320) at dilution of 1:400 (400x lens) |
| Immunohistochemistry of paraffin embedded rat brain using DLL1 (GB11320) at dilution of 1:400 (400x lens) |
| Immunohistochemistry of paraffin embedded rat spinal cord using DLL1 (GB11320) at dilution of 1:400 (400x lens) |
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Immunofluorescence of paraffin embedded rat brain using DLL1 (GB11320) at dilution of 1:200 (400x lens) |
| Immunofluorescence of paraffin embedded rat lung using DLL1 (GB11320) at dilution of 1:200 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
