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Anti-DOCK2 Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DOCK2 rabbit polyclonal antibody |
Gene Name: | Dedicator of cytokinesis protein 2 |
Synonyms: | Protein Hch, Dock2, Dedicator of cyto kinesis 2, KIAA0209, Dedicator of cytokinesis 2 |
Immunogen: | Recombinant protein corresponding to Mouse DOCK2 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 212 kDa |
Observed MW. | 220 kDa |
Uniprot ID: | Q92608, Q8C3J5 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lymph node, spleen |
Background
The DOCK2 gene encodes dedicator of cytokinesis 2 (DOCK 2), a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. DOCK 2 participates in the cytoskeletal rearrangements that are required for lymphocyte migration in response of chemokines. DOCK 2 may also participate in IL-2 transcriptional activation through the activation of Rac 2. DOCK 2 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. The DOCK 2 protein also co-localizes with F-Actin, and demonstrates expression in several human tissues, with the highest levels observed in peripheral blood leukocytes, thymus, spleen and liver.
Images
| Western blot analysis of DOCK2 (GB112101) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
