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| Reactivity: | H,M |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DPYS rabbit polyclonal antibody |
Gene Name: | Dihydropyrimidinase |
Synonyms: | DHP, DHPase, DPYS, Hydantoinase, Dihydropyrimidine amidohydrolase |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse DPYS |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm |
Uniprot ID: |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Rat | 1: 600-1: 1200 | kidney |
Background
DPYS(Dihydropyrimidinase)also known as 5,6-dihydropyrimidine amidohydrolase, or DHP, is the second enzyme in uracil and thymine catabolism. However, in normal human extrahepatic tissues, DPYS, rather than dihydrouracil dehydrogenase, is the rate-limiting enzyme in the pyrimidine base catabolic pathway. DHPase in solid tumors is increased when compared with normal tissues.Defects in DPYS are the cause of dihydropyrimidinase deficiency (DHPD).
Images
 | Immunofluorescent analysis of paraformaldehyde-fixed rat kidney using DPYS (GB113842) at dilution of 1: 1200 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |