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| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | DcR3 rabbit polyclonal antibody |
Gene Name: | Tumor necrosis factor receptor superfamily member 6B |
Synonyms: | Decoy receptor 3, DcR3, Decoy receptor for Fas ligand, M68, TR6, TNFRSF6B, M68E, UNQ186/PRO212 |
Immunogen: | Recombinant protein corresponding to Human DcR3 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Predicted MW. | 33 kDa |
Observed MW. | 33 kDa |
Uniprot ID: | O95407 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, lung |
IHC/IF | Human, Mouse, Rat | 1: 700-1: 1400 | colon, colon cancer, gastric cancer, small intestine, tonsil |
Background
Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively. Unlike DcR1and DcR2, DcR3 is a soluble rather than a membraneassociated molecule. DcR3 binds to FasL and LIGHT andinhibits FasL and LIGHT induced apoptosis.
Images
 | Western blot analysis of DCR3 (GB112102) at dilution of 1: 500 |
 | Immunofluorescence of paraffin embedded human colon cancer using DCR3 (GB112102) at dilution of 1: 700 (400x lens) |
 | Immunofluorescence of paraffin embedded human gastric cancer using DCR3 (GB112102) at dilution of 1: 700 (400x lens) |
 | Immunofluorescence of paraffin embedded human tonsil using DCR3 (GB112102) at dilution of 1: 700 (350x lens) |
 | Immunofluorescence of paraffin embedded mouse small intestine using DCR3 (GB112102) at dilution of 1: 700 (400x lens) |
 | Immunofluorescence of paraffin embedded rat colon using DCR3 (GB112102) at dilution of 1: 700 (450x lens) |
| Immunofluorescence of paraffin embedded rat small intestine using DCR3 (GB112102) at dilution of 1: 700 (450x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
