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Anti-Desmin Rabbit pAb (100 μl)
| Reactivity: | M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Desmin rabbit polyclonal antibody |
Gene Name: | Desmin |
Synonyms: | DES, CSM1, CSM2, LGMD2R, desmin |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse desmin |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Cell membrane |
Predicted MW. | 54 kDa |
Observed MW. | 55 kDa |
Uniprot ID: | P31001, P48675 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 1000-1: 2000 | heart |
IHC/IF | Human, Mouse, Rat | 1: 500-1: 2000 | endometrial cancer, metrocarcinoma |
Background
Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures . May act as a sarcomeric microtubule-anchoring protein: specifically associates with detyrosinated tubulin-alpha chains, leading to buckled microtubules and mechanical resistance to contraction.
Images
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Western blot analysis of Desmin (GB11081) at dilution of 1: 1000 |
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Immunofluorescence of paraffin embedded human endometrial cancer using Desmin (GB11081) at dilution of 1: 500 (400x lens) |
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Immunofluorescence of paraffin embedded human metrocarcinoma using Desmin (GB11081) at dilution of 1: 500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
