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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Dnmt1 rabbit polyclonal antibody |
Gene Name: | DNA (cytosine-5)-methyltransferase 1 |
Synonyms: | DNA (cytosine-5-)-methyltransferase 1,DNA methyltransferase 1, DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Dnmt1 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus |
Uniprot ID: | P13864, P26358 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human | 1: 500-1: 2000 | colon, kidney, lung, stomach, thyroid gland |
Background
Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2.
Images
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Immunohistochemistry analysis of paraffin-embedded human lung cancer using Dnmt1 (GB11328) at dilution of 1:800 |
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Immunohistochemistry analysis of paraffin-e mbedded human liver cancer using Dnmt1 (GB11328) at dilution of 1:800 |
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Immunohistochemistry of paraffin embedded human lung using Dnmt1 (GB11328) at dilution of 1:1000 (400x lens) |
| Immunofluorescence of paraffin embedded human stomach using Dnmt1 (GB11328) at dilution of 1:500 (400x lens) |
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Immunofluorescence of paraffin embedded human thyroid gland using Dnmt1 (GB11328) at dilution of 1:500 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
