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| Reactivity: | H |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Transcription factor E2F1 |
Synonyms: | E2F-1, RBAP1, RBBP3, RBP3, E2F transcription factor 1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse E2F1 |
Uniprot ID: | Q61501 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 46 kDa / 55-60 kDa |
Product Usage Information
WB | Human | 1: 300-1: 400 | Hela, jurkat |
Background
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters Positively regulates transcription of RRP1B (By similarity).
Images
| WB analysis of E2F 1 (GB115516). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
