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Anti-EIF3F Rabbit pAb (100 μl)
| Reactivity: | H,M,R | |||||||||||||||||||||||||||||||
| Applications: | WB | |||||||||||||||||||||||||||||||
| Host Species: | Rabbit | |||||||||||||||||||||||||||||||
| Clonality: | Polyclonal | |||||||||||||||||||||||||||||||
Product Usage Information
Background EIF3F is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2: GTP: methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Images
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