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Anti-EPCR/CD201 Rabbit pAb (100 μl)
| Reactivity: | H & H,M |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | EPCR/CD201 rabbit polyclonal antibody |
Gene Name: | Endothelial protein C receptor |
Synonyms: | Activated protein C receptor, APC receptor, Centrocyclin, Centrosomal protein CCD41, Endothelial cell protein C receptor, CD201, Procr, Epcr |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse CD201 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Membrane |
Predicted MW. | 27 kDa |
Observed MW. | 46 kDa |
Uniprot ID: | Q9UNN8 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human | 1: 500-1: 1000 | A549, HT-29, THP-1 |
IHC/IF | Human, Mouse | 1: 600-1: 1200 | heart, lung cancer |
Background
EPCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. It is an N glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. It is expressed strongly in the endothelial cells of arteries and veins in heart and lung. It is overexpressed in several human non-Pgp multidrug resistant (MDR) tumor cell lines.
Images
| Western blot analysis of CD201 (GB112210) at dilution of 1: 500 |
| Immunofluorescence of paraffin embedded human lung cancer using CD201 (GB112210) at dilution of 1: 600 (250x lens) |
| Immunofluorescence of paraffin embedded mouse heart using CD201 (GB112210) at dilution of 1: 600 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
