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| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | ErbB2 rabbit polyclonal |
Gene Name: | Receptor tyrosine-protein kinase erbB-2 |
Synonyms: | ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, Erb-b2 receptor tyrosine kinase 2 |
Immunogen: | Recombinant protein corresponding to Mouse ErbB2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cytoplasm, Nucleus, Cell membrane |
Uniprot ID: | P04626 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
IHC | Human | 1: 500-1: 4000 | colon |
IF | Human | 1: 500-1: 1000 | colon |
Background
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 (rodent) or ERBB2 (human), is a protein that in humans is encoded by the ERBB2 gene. ERBB is abbreviated from erythroblastic oncogene B, a gene isolated from avian genome. It is also frequently called HER2 (from human epidermal growth factor receptor 2) or HER2/neu. HER2 is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. Amplification or over-expression of this oncogene has been shown to play an important role in the development and progression of certain aggressive types of breast cancer. In recent years the protein has become an important biomarker and target of therapy for approximately 30% of breast cancer patients.
Images
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Immunohistochemistry analysis of paraffin-embedded human colon using ErbB2 (GB11547) at dilution of 1: 500 |
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Immunohistochemistry analysis of paraffin-embedded human colon using ErbB2 (GB11547) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
