Reactivity: | H,M,R |
Applications: | WB |
Host Species: | Rabbit |
Clonality: | Polyclonal |
Gene Name: | Erlin-2 |
Synonyms: | C8orf2, ER lipid raft associated 2, Erlin 2, ERLIN2, NET32, SPFH2 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Erlin-2 |
Uniprot ID: | Q8BFZ9 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 38 kDa / 43 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain, kidney |
Background
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex .
Images
Western blot analysis of ERLIN2 (GB114666) at dilution of 1: 1000 |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |