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| Reactivity: | H |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Fatty acid 2-hydroxylase |
Synonyms: | FA2H, FAAH, FAH1, fatty acid 2 hydroxylase, Fatty acid alpha hydroxylase, FAXDC1, SCS7 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FA2H |
Uniprot ID: | Q5MPP0 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Endoplasmic reticulum, Membrane, Microsome |
Product Usage Information
IHC/IF | Human | 1: 300-1: 900 | colon |
Background
Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis . FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids . Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath . Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis .
Images
| Immunohistochemistry analysis of paraffin embedded human colon using FA2H (GB114704) at dilution of 1: 300 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
