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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FAK rabbit polyclonal antibody |
Gene Name: | Focal adhesion kinase 1 |
Synonyms: | PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2 |
Immunogen: | Recombinant protein corresponding to Mouse FAK |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Plasma membrane, Cytoskeleton |
Uniprot ID: | Q05397, P34152, O35346 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Mouse, Rat | 1:1000-1:2000 | brain, breast cancer, heart, kidney |
Background
FAK is a protein of 125 kD recruited as a participant in focal adhesion dynamics between cells, and has a role in motility and cell survival. FAK is a highly conserved, non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine kinase v-src. This cytosolic kinase has been implicated in diverse cellular roles including cell locomotion, mitogen response and cell survival.
Images
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Immunohistochemistry of paraffin embedded human breast cancer using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded human kidney using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse brain using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded mouse brain using FAK (GB11545) at dilution of 1:1000 (400x lens) |
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Immunofluorescence of paraffin embedded rat heart using FAK (GB11545) at dilution of 1:1000 (400x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |