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Anti-FAM123B Rabbit pAb (100 μl)
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FAM123B rabbit polyclonal antibody |
Gene Name: | APC membrane recruitment protein 1 |
Synonyms: | Amer1, AMER1, wtx, OSCS, Wilms tumor gene on the X chromosome protein, Wilms tumor on the X, WTX |
Immunogen: | Recombinant protein corresponding to Mouse FAM123B |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 125 kDa |
Observed MW. | 125 kDa |
Uniprot ID: | Q5JTC6, Q7TS75 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Mouse, Rat | 1:500-1:1000 | kidney, brain, lung |
Background
Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.
Images
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Western blot analysis of wtx (GB11816) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |