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Anti-FCGBP Rabbit pAb (100 μl)
| Reactivity: | H,R |
| Applications: | IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FCGBP rabbit polyclonal antibody |
Gene Name: | IgGFc-binding protein |
Synonyms: | Fcgamma-binding protein antigen, FcgammaBP, FCGBP, Fc fragment of IgG binding protein |
Immunogen: | Recombinant protein corresponding to Human FCGBP |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Secreted |
Uniprot ID: | Q9Y6R7 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Rat | 1: 500-1: 1500 | colon |
Background
Fc (Ig constant fragment) receptors ensure protection of the host against foreign antigens, such as microorganisms and pathogens, by removing Ig-coated antigen complexes from circulation. Fc receptors are present on lymphoid and myeloid derivatives, where they mediate endocytosis of Ig-antigen complexes, antibody production in B cells through T cell antigen presentation, cytotoxicity and the release of cytokines and reactive oxygen species. The Fc γ-binding protein (FCGBP) interacts with the Fc portion of IgG and MUC2 to mediate the maintenance of the mucosal structure. FCGBP is a 5,405 amino acid protein that contains twelve TIL (trypsin inhibitory-like) domains and thirteen VWFD domains.
Images
| Immunohistochemistry of paraffin embedded human colon using FCGBP (GB112030) at dilution of 1:800 (250x lens) |
| Immunohistochemistry of paraffin embedded rat colon using FCGBP (GB112030) at dilution of 1:800 (250x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
