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Anti-FCGRT/FCRN Rabbit pAb (100 μl)
| Reactivity: | M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FCGRT/FCRN rabbit polyclonal antibody |
Gene Name: | IgG receptor FcRn large subunit p51 |
Synonyms: | FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, Fcgrt |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FCGRT |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 40 kDa |
Observed MW. | 40 kDa |
Uniprot ID: | Q61559 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Mouse | 1: 500-1: 1000 | liver, kidney, small intestine |
Background
FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.
Images
| Western blot analysis of FCGRT (GB112081) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
