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| Reactivity: | H,M |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FEN1 rabbit polyclonal antibody |
Gene Name: | Flap endonuclease 1 |
Synonyms: | FEN-1, Flap structure-specific endonuclease 1, Fen1, Fen-1, DNase IV, flap structure endonuclease 1, hFEN 1, Maturation factor 1, MF1, RAD2 |
Immunogen: | Recombinant protein corresponding to Mouse FEN1 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 42 kDa |
Observed MW. | 45 kDa |
Uniprot ID: | P39748, P39749 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse | 1: 500-1: 1000 | lung, testis, small intestine |
Background
FEN1(Flap endonuclease-1) is the prototypical member of the 5’-nuclease superfamily, whose activities span a range of cellular pathways involved in DNA replication and genome maintenance . FEN1 is a structure-selective metallonuclease essential for Okazaki fragment maturation through efficient removal of 5’ flaps resulting from strand displacement during lagging-strand synthesis. FEN1 is overexpressed in multiple cancer types, and has been suggested both as a biomarker relating to prognosis and disease progression and as a potential therapeutic target.
Images
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Western blot analysis of FEN1 (GB111455) at dilution of 1: 500 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
