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| Reactivity: | H,M,R & H,M,R |
| Applications: | WB & IHC/IF |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | FGF2 rabbit polyclonal antibody |
Gene Name: | Fibroblast growth factor 2 |
Synonyms: | FGFB, FGF-2, Basic fibroblast growth factor, HBGH2, HBGF-2, Prostatropin, Heparin binding growth factor 2 precursor, BFGF |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human FGF2 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Nucleus, Secreted |
Uniprot ID: | P09038 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
IHC/IF | Human, Rat (Predicted: Mouse) | 1: 1000-1: 2000 | placenta, pituitary gland |
Background
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Images
 | Immunohistochemistry of paraffin embedded human placenta using FGF2 (GB113970) at dilution of 1: 2000 (200x lens) |
 | Immunohistochemistry of paraffin embedded rat placenta using FGF2 (GB113970) at dilution of 1: 2000 (200x lens) |
 | Immunohistochemistry of paraffin embedded rat pituitary gland using FGF2 (GB113970) at dilution of 1: 2000 (200x lens) |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
