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Anti-FGFR2 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Fibroblast growth factor receptor 2 |
Synonyms: | BEK, BFR 1, CD332, CEK3, CFD1, ECT1, FGFR 2, FGFR2, JWS, K SAM, KGFR, KSAM, TK14, TK25 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse FGFR2 |
Uniprot ID: | P21803 |
Isotype: | lgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 92 kDa / 145 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 300-1: 500 | lung |
Background
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.
Images
| WB analysis of FGFR2 (GB115514). |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
