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| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Ferroptosis suppressor protein 1 |
Synonyms: | AIFM2, AMID, PRG3, p53-responsive gene 3 protein, FSP1 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human FSP1 |
Uniprot ID: | Q9BRQ8 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Lipid droplet,Cell membrane,Cytoplasm,Mitochondrion membrane,Nucleus |
Predicted MW. / Observed MW. | 41 kDa / 41 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | liver, heart, brown adipose tissue |
Background
A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way.
Images
| Western blot analysis of FSP1 (GB115322) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
