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Anti-Factor I/CFI Rabbit pAb (100 μl)
| Reactivity: | H,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Factor I/CFI rabbit polyclonal antibody |
Gene Name: | Complement factor I |
Synonyms: | C3B/C4B inactivator, Cfi, If, AHUS3, ARMD13, C3b inactivator, C3BINA, FactorI, Konglutinogen activating factor |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse Factor I/CFI |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 67 kDa |
Observed MW. | 70 kDa |
Uniprot ID: | P05156, Q9WUW3 |
Product Usage Information
Applications | Species | Dilution | Positive tissue |
WB | Human, Rat | 1: 250-1: 500 | kidney |
Background
Trypsin-like serine protease that plays an essential role in regulating the immune response by controlling all complement pathways. Inhibits these pathways by cleaving three peptide bonds in the alpha-chain of C3b and two bonds in the alpha-chain of C4b thereby inactivating these proteins. Essential cofactors for these reactions include factor H and C4BP in the fluid phase and membrane cofactor protein/CD46 and CR1 on cell surfaces. The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization.
Images
 | Western blot analysis of CFI (GB112386) at dilution of 1: 250 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
