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| Reactivity: | Mouse |
| Applications: | FCM, IC |
| Host Species: | Rat |
| Isotype: | Rat IgG1, κ |
| Clonality: | Monoclonal |
| Conjugation: | AF647 |
| Synonyms: | Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8 |
| Background: | IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course. |
| Gene ID: | 16171 |
| SwissProt: | Q62386 |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Storage: | Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. |
| Documents: | Please contact us to request the manual |
