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| Reactivity: | Mouse |
| Applications: | FCM |
| Host Species: | Rat |
| Isotype: | Rat IgG2a, κ |
| Clonality: | Monoclonal |
| Conjugation: | APC |
| Synonyms: | TIM3, TIMD3,HAVcr-2,TIMD-3 |
| Background: | CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. |
| Gene ID: | 84868 |
| SwissProt: | Q8VIM0 |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Storage: | Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. |
| Documents: | Please contact us to request the manual |
