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Reactivity: | Human |
Applications: | FCM |
Host Species: | Mouse |
Isotype: | Mouse IgG2b, κ |
Clonality: | Monoclonal |
Conjugation: | PE |
Synonyms: | Receptor-type tyrosine-protein phosphatase C,Ptprc,L-CA,Ly-5,T200,CD45 |
Background: | CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines. |
Gene ID: | 5788 |
SwissProt: | P08575 |
Buffer: | PBS with 0.05% Proclin300, 1% BSA |
Storage: | Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. |
Documents: | Please contact us to request the manual |