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| Reactivity: | Mouse |
| Applications: | FCM |
| Host Species: | Rat |
| Isotype: | Rat IgG2b, κ |
| Clonality: | Monoclonal |
| Conjugation: | Unconjugated |
| Synonyms: | B7-H1, PD-L1, Programmed cell death ligand 1, B7 homolog 1, B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1 |
| Background: | CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production. |
| Gene ID: | 60533 |
| SwissProt: | Q9EP73 |
| Concentration: | 0.5 mg/mL |
| Buffer: | PBS with 0.05% Proclin300 |
| Storage: | Store at 2~8°C. Do not freeze. |
| Documents: | Please contact us to request the manual |
