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Anti-Frizzled 6 Rabbit pAb (100 μl)
| Reactivity: | M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Full Name: | Frizzled 6 rabbit polyclonal antibody |
Gene Name: | Frizzled-6 |
Synonyms: | Fz-6, mFz6, Fzd6, NDNC10, Frizzled homolog 6, Frizzled family receptor 6, Frizzled 6 seven transmembrane spanning receptor, hFz6 |
Immunogen: | Recombinant protein corresponding to Mouse Frizzled 6 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. | 79 kDa |
Observed MW. | 72 kDa |
Uniprot ID: | Q61089 |
Product Usage Information
Applications | Species | Dilution | Positive Sample |
WB | Mouse, Rat | 1: 1000-1: 2000 | liver, kidney, prostate, pancreas |
Background
This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis.
Images
 | Western blot analysis of Frizzled-6 (GB112220) at dilution of 1: 1000 |
Storage
| Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
