Reactivity: | M,R & M,R |
Applications: | WB & IHC/IF |
Host Species: | Mouse |
Clonality: | Monoclonal ) |
Gene Name: | Neuromodulin |
Synonyms: | GAP43, B-50, PP46, growth associated protein 43 |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Mouse GAP43 |
Uniprot ID: | P06837/P07936 |
Isotype: | IgG |
Purity: | Affinity purification |
Subcellular location: | Cell membrane |
Predicted MW. / Observed MW. | 43 kDa / 43 kDa |
Product Usage Information
WB | Mouse, Rat | 1: 500-1: 1000 | cerebral cortex, brain |
IHC/IF | Mouse, Rat | 1: 500-1: 1000 | brain |
Background
GAP43 has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development, during axonal regeneration and is phosphorylated after long-term potentiation(LTP) and after learning (reference needed). This protein is considered a crucial component of the axon andpresynaptic terminal, its null mutation leading to death within days after birth due to axon pathfinding defects.
Images
Western blot analysis of GAP43 (GB15095) at dilution of 1: 1000 | |
Immunohistochemistry analysis of paraffin embedded mouse brain using GAP43 (GB15095) at dilution of 1: 1000 | |
Immunohistochemistry analysis of paraffin embedded rat brain using GAP43 (GB15095) at dilution of 1: 1000 |
Storage
Storage | Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |